Clearly compensating
Genetic compensation by transcriptional adaptation is a process whereby knocking out a gene (e.g by CRISPR or TALEN) results in the deregulation of genes that make up for the loss of gene function. A 2015 study by Rossi et al. (discussed previously) alerted researchers that CRISPR/TALEN knock-out experiments may be subject to such effects. Genetic adaption or compensation had been well known to mouse researchers creating knock-out lines. In fact, one of our company founders also ran into this when trying to confirm Read More