
Performing target validation well
Summary This blogpost describes issues encountered in target validation and how to safeguard against poor reproducibility in RNAi experiments. The importance of target validation More than half of all clinical trials fail from a lack of drug efficacy. One of the major reasons for this is inadequate target validation. Target validation involves verifying whether a target (protein/nucleic acid) merits the development of a drug (small molecule/biologic) for therapeutic application. Failing to adequately validate a target can burden a pharma with roughly 800 million to 1.4 billion in Read More